CYP2C19

Across TCGA cell cohorts, CYP2C19 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP2C19-associated genes across cancer lineages are FAM71A, RAX2, and RESP18. Each is linked with CYP2C19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C19-to-partner and partner-to-CYP2C19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71A grouped by CYP2C19-low versus CYP2C19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C19→partner) and Y-score (partner→CYP2C19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	+0.054	+3.453	.004	.009	3	1
LARGE_INTESTINE	RAX2 →	+0.073	+3.196	<.001	.007	3	1
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1
BLOOD_Leukemia	SLC22A12 →	+0.006	+5.539	<.001	.003	3	1
SKIN	ANGPTL8 →	+0.135	+3.736	.002	.004	3	1
SKIN	PRAC1 →	+0.163	+3.000	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FAM71A by CYP2C19 expression — LARGE_INTESTINE

Explore this box plot interactively →