CYP2C18

Across TCGA patient cohorts, CYP2C18 protein abundance is significantly associated with the RNA expression of many other genes, with 7,053 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CYP2C18-associated genes across cancer lineages are MMP9, SPEF1, and CA2. Each is linked with CYP2C18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C18-to-partner and partner-to-CYP2C18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP2C18 versus MMP9 in PDAC, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C18→partner) and Y-score (partner→CYP2C18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MMP9 →	-2.217	-1.043	<.001	<.001	3	1
PDAC	SPEF1 →	-0.403	-0.660	.002	.008	3	1
PDAC	CA2 →	+1.719	+1.003	.001	.002	3	1
PDAC	COL9A1 →	+1.331	+0.941	<.001	<.001	3	1
PDAC	CNTN3 →	+1.473	+0.984	<.001	.006	3	1
PDAC	SLC5A9 →	+0.680	+0.713	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,053 associations by consensus.

CYP2C18 vs MMP9 — PDAC

Explore this scatter interactively →