CYP2C18

Across TCGA patient cohorts, CYP2C18 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2C18-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Caspase-8. Each is linked with CYP2C18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C18-to-partner and partner-to-CYP2C18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CYP2C18-low versus CYP2C18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C18→partner) and Y-score (partner→CYP2C18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.377	+2.807	.005	.002	3	2
UCEC	p62 Lck ligand →	+0.272	+3.469	.026	.002	3	2
UCEC	Caspase-8 →	-0.185	-2.558	.049	.010	3	2
UCEC	Cyclin-B1 →	+0.679	+3.807	.001	<.001	3	2
SKCM	ACC1 →	+0.200	+2.115	.037	.015	3	2
SKCM	XBP1 →	-0.152	-2.000	.045	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

MEK1 by CYP2C18 expression — UCEC

Explore this box plot interactively →