CYP2C18

Across TCGA cell cohorts, CYP2C18 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2C18-associated genes across cancer lineages are OR2A4, OR5M10, and MAGEB4. Each is linked with CYP2C18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C18-to-partner and partner-to-CYP2C18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A4 grouped by CYP2C18-low versus CYP2C18-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C18→partner) and Y-score (partner→CYP2C18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2A4 →	+0.067	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.014	+4.662	<.001	.005	3	1
BLOOD_Leukemia	MAGEB4 →	+0.037	+3.705	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.093	+3.855	<.001	.007	3	1
BLOOD_Leukemia	MAGEB6 →	+0.313	+3.978	<.001	.005	3	1
BLOOD_Leukemia	OR5H6 →	+0.341	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2A4 by CYP2C18 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →