CYP2B7P

Across TCGA patient cohorts, CYP2B7P mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2B7P-associated genes across cancer lineages are p62 Lck ligand, Rab11, and VHL. Each is linked with CYP2B7P in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2B7P-to-partner and partner-to-CYP2B7P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CYP2B7P-low versus CYP2B7P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2B7P→partner) and Y-score (partner→CYP2B7P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.389	+3.807	.007	<.001	3	1
UCEC	Rab11 →	-0.168	-2.700	.010	.006	3	1
UCEC	VHL →	-0.778	-2.000	.011	.032	3	1
UCEC	Caspase-8 →	-0.282	-3.432	.012	.005	3	1
UCEC	4E-BP1 →	+0.419	+2.999	<.001	.035	3	1
UCEC	JNK2 →	+0.276	+3.179	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p62 Lck ligand by CYP2B7P expression — UCEC

Explore this box plot interactively →