Across TCGA patient cohorts, CYP2B6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2B6-associated genes across cancer lineages are Stathmin, Cyclin-B1, and XBP1. Each is linked with CYP2B6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2B6-to-partner and partner-to-CYP2B6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2B6→partner) and Y-score (partner→CYP2B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Stathmin →	+0.136	+1.610	.028	.040	3	3
SKCM	Cyclin-B1 →	+0.320	+1.334	.023	.041	3	3
UCEC	XBP1 →	-0.160	-1.502	.001	.027	3	2
UCEC	Di-Ras3 →	-0.150	-3.571	.004	.002	3	2
SKCM	STAT5a →	+0.402	+2.017	.035	.015	3	2
UCEC	eIF4E →	+0.155	+1.750	.037	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

CYP2B6 survival (RNA) · tumor vs normal (RNA) · all CYP2B6 data types