Across TCGA cell cohorts, CYP2B6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2B6-associated genes across cancer lineages are IL17F, TREML4, and AADACL2. Each is linked with CYP2B6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2B6-to-partner and partner-to-CYP2B6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2B6→partner) and Y-score (partner→CYP2B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL17F →	+0.028	+5.632	<.001	<.001	3	1
SKIN	TREML4 →	+0.031	+3.684	<.001	.006	3	1
BLOOD_Lymphoma	AADACL2 →	+0.020	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	PRAMEF7 →	+0.074	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	ZNF728 →	+1.130	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRT33A →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

CYP2B6 survival (RNA) · tumor vs normal (RNA) · all CYP2B6 data types