Across TCGA cell cohorts, CYP2B6 mutation is significantly associated with the mutation status of many other genes, with 1,706 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2B6-associated genes across cancer lineages are PSTPIP1, FNBP1, and PCBP4. Each is linked with CYP2B6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2B6-to-partner and partner-to-CYP2B6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2B6→partner) and Y-score (partner→CYP2B6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PSTPIP1 →	+5.053	+4.239	.007	.007	1	3
BLOOD_Lymphoma	FNBP1 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	PCBP4 →	+4.584	+4.584	.007	.007	1	3
SKIN	CHD4 →	+4.053	+4.357	.001	.001	1	3
SKIN	USP5 →	+5.053	+4.239	.007	.007	1	3
BLOOD_Leukemia	IRF2BPL →	+2.823	+3.665	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

Exploration

CYP2B6 survival (RNA) · tumor vs normal (RNA) · all CYP2B6 data types