Across TCGA pan-cancer cohorts, CYP2AC1P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CYP2AC1P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where CYP2AC1P RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2AC1P is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.
THCA, BRCA, and LUSC are the cancer types where CYP2AC1P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2AC1P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.