Across TCGA pan-cancer cohorts, CYP2A7P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CYP2A7P1’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where CYP2A7P1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2A7P1 is over-expressed in tumor, although a few such as CHOL and LIHC show the opposite, repressed pattern.

CHOL, LIHC, and LUAD are the cancer types where CYP2A7P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2A7P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	−0.393	.003	5	view →
LIHC	Male	II,III,IV	−0.135	.009	2	view →
LUAD	All	II,III,IV	−0.030	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: CYP2A7P1 RNA expression & survival · all CYP2A7P1 data types