CYP2A6

Across TCGA patient cohorts, CYP2A6 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2A6-associated genes across cancer lineages are Notch1, MEK1, and p27_pT198. Each is linked with CYP2A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2A6-to-partner and partner-to-CYP2A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CYP2A6-low versus CYP2A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A6→partner) and Y-score (partner→CYP2A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.171	+1.678	.001	.023	3	2
UCEC	MEK1 →	+0.375	+3.169	.007	.018	3	1
UCEC	p27_pT198 →	+0.112	+3.700	.006	.001	2	2
UCEC	p38-MAPK →	-0.178	-2.787	.004	.003	3	1
UCEC	STAT3_pY705 →	-0.317	-1.700	.001	.040	3	1
UCEC	TIGAR →	+0.143	+1.704	.014	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by CYP2A6 expression — UCEC

Explore this box plot interactively →