CYP2A6

Across TCGA cell cohorts, CYP2A6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2A6-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Regulation of myoblast fusion, and Fertilization. Each is linked with CYP2A6 in more than 8 cancer types. Because this analysis shows association rather than direction, both CYP2A6-to-partner and partner-to-CYP2A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by CYP2A6-low versus CYP2A6-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A6→partner) and Y-score (partner→CYP2A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of RNA splicing →	+0.071	+0.140	<.001	<.001	3	9
CNS	Regulation of myoblast fusion →	+0.065	+0.131	<.001	.008	3	9
LARGE_INTESTINE	Fertilization →	-0.058	-0.057	<.001	<.001	3	8
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.072	+0.169	.001	.005	3	8
BLOOD_Leukemia	Nucleic acid catabolic process →	+0.034	+0.116	.001	.009	3	8
STOMACH	Negative regulation of mRNA splicing, via spliceosome →	+0.087	+0.167	.009	.007	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,865 associations by consensus.

Negative regulation of RNA splicing by CYP2A6 expression — BLOOD_Leukemia

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