Across TCGA pan-cancer cohorts, CYP27C1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CYP27C1 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CYP27C1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP27C1 expression acts as an unfavorable survival marker.

COAD and HNSC are the cancer types where CYP27C1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.375	0.695	.019	12	view →
HNSC	OS	Median	IV	0.155	0.639	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: CYP27C1 tumor-vs-normal RNA expression · all CYP27C1 data types