Across TCGA patient cohorts, CYP27C1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,381 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CYP27C1-associated genes across cancer lineages are LIPG, GALNT18, and VDR. Each is linked with CYP27C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27C1-to-partner and partner-to-CYP27C1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27C1→partner) and Y-score (partner→CYP27C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LIPG →	+1.033	+1.595	.001	.004	3	2
BRCA	GALNT18 →	+1.871	+1.595	.002	.004	3	2
BRCA	VDR →	+1.278	+1.595	.005	.004	3	2
HNSC	LIPK →	+1.016	+0.773	<.001	.001	3	2
HNSC	ANK2 →	-1.212	-1.110	<.001	.001	3	2
GBM	NR3C2 →	-0.998	-1.408	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,381 associations by consensus.

Exploration

CYP27C1 survival (RNA) · tumor vs normal (RNA) · all CYP27C1 data types