Across TCGA patient cohorts, CYP27C1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP27C1-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and eIF4E. Each is linked with CYP27C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27C1-to-partner and partner-to-CYP27C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27C1→partner) and Y-score (partner→CYP27C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.135	-2.202	.013	.010	3	2
UCEC	EGFR_pY1068 →	-0.241	-2.000	.008	.029	3	1
UCEC	eIF4E →	+0.211	+3.000	.006	<.001	3	1
UCEC	A-Raf_pS299 →	-0.112	-2.584	.010	.010	3	1
UCEC	FoxM1 →	+0.323	+1.847	<.001	.008	3	1
UCEC	GAPDH →	+0.427	+2.459	.030	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

CYP27C1 survival (RNA) · tumor vs normal (RNA) · all CYP27C1 data types