Across TCGA cell cohorts, CYP27C1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP27C1-associated genes across cancer lineages are CSN2, OR12D3, and GPR42. Each is linked with CYP27C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27C1-to-partner and partner-to-CYP27C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27C1→partner) and Y-score (partner→CYP27C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.104	+5.415	<.001	.004	3	2
LARGE_INTESTINE	OR12D3 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPR42 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	LMNTD1 →	+0.140	+3.554	<.001	.007	3	1
LARGE_INTESTINE	NKAIN3 →	+0.428	+3.936	<.001	.002	3	1
LARGE_INTESTINE	GK2 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

CYP27C1 survival (RNA) · tumor vs normal (RNA) · all CYP27C1 data types