CYP27B1

Across TCGA patient cohorts, CYP27B1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP27B1-associated genes across cancer lineages are eEF2, ERK2, and JNK_pT183_Y185. Each is linked with CYP27B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27B1-to-partner and partner-to-CYP27B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CYP27B1-low versus CYP27B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27B1→partner) and Y-score (partner→CYP27B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.279	+1.874	.030	.049	3	2
UCEC	ERK2 →	+0.180	+1.906	.009	.015	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-2.321	<.001	.005	3	2
UCEC	PCNA →	+0.270	+3.087	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.571	+2.242	.007	.005	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.925	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by CYP27B1 expression — UCEC

Explore this box plot interactively →