CYP27B1

Across TCGA cell cohorts, CYP27B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,358 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYP27B1-associated GO terms across cancer lineages are Vitamin D catabolic process, mRNA 5'-splice site recognition, and Microtubule nucleation. Each is linked with CYP27B1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CYP27B1-to-partner and partner-to-CYP27B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vitamin D catabolic process grouped by CYP27B1-low versus CYP27B1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27B1→partner) and Y-score (partner→CYP27B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Vitamin D catabolic process →	+1.410	+1.587	<.001	<.001	3	10
BONE	mRNA 5'-splice site recognition →	+0.124	+1.339	<.001	.001	2	9
BONE	Microtubule nucleation →	+0.123	+0.953	<.001	.002	3	8
LUNG_SCLC	Regulation of tRNA catabolic process →	+0.164	+0.952	<.001	<.001	3	8
LUNG_SCLC	Negative regulation of tRNA catabolic process →	+0.164	+0.952	<.001	<.001	3	8
LUNG_SCLC	Regulation of tRNA stability →	+0.164	+0.952	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,358 associations by consensus.

Vitamin D catabolic process by CYP27B1 expression — BLOOD_Lymphoma

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