CYP27B1

Across TCGA cell cohorts, CYP27B1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP27B1-associated genes across cancer lineages are C16orf96, GSG1L2, and MYL10. Each is linked with CYP27B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27B1-to-partner and partner-to-CYP27B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf96 grouped by CYP27B1-low versus CYP27B1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27B1→partner) and Y-score (partner→CYP27B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
BLOOD_Leukemia	MYL10 →	+0.018	+4.569	<.001	.003	3	1
BLOOD_Leukemia	LYZL4 →	+0.040	+3.567	.007	.003	3	1
BLOOD_Leukemia	OR4K2 →	+0.020	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C16orf96 by CYP27B1 expression — LARGE_INTESTINE

Explore this box plot interactively →