Across TCGA patient cohorts, CYP26C1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP26C1-associated genes across cancer lineages are mTOR_pS2448, p62 Lck ligand, and p27_pT198. Each is linked with CYP26C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26C1-to-partner and partner-to-CYP26C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26C1→partner) and Y-score (partner→CYP26C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.198	-3.000	.021	.037	3	1
UCEC	p62 Lck ligand →	+0.450	+2.817	.016	.036	3	1
UCEC	p27_pT198 →	+0.169	+3.000	.006	.037	1	1
UCEC	PCNA →	+0.362	+3.000	.003	.037	1	1
UCEC	Bak →	+0.438	+3.000	.002	.037	1	1
UCEC	Cyclin-E2 →	+0.274	+3.000	.004	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

CYP26C1 survival (RNA) · tumor vs normal (RNA) · all CYP26C1 data types