Across TCGA cell cohorts, CYP26C1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP26C1-associated genes across cancer lineages are OPRPN, C16orf90, and ALLC. Each is linked with CYP26C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26C1-to-partner and partner-to-CYP26C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26C1→partner) and Y-score (partner→CYP26C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	ALLC →	+0.100	+4.000	<.001	.002	3	1
LUNG_NSCLC_LUAD	GOLGA6L2 →	+0.104	+3.906	<.001	.003	3	1
LUNG_NSCLC_LUAD	SIGLECL1 →	+0.018	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	SSX7 →	+0.016	+4.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CYP26C1 survival (RNA) · tumor vs normal (RNA) · all CYP26C1 data types