CYP26B1

Across TCGA pan-cancer cohorts, CYP26B1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated CYP26B1 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYP26B1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP26B1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and CESC are the cancer types where CYP26B1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.941	0.431	.009	28	view →
HNSC	OS	Median	IV	0.082	0.708	<.001	18	view →
CESC	DFS	Median	II,III,IV	0.238	0.710	.015	12	view →
SCLC	OS	Median	All	0.219	0.587	.017	9	view →
STAD	DFS	Median	All	0.264	0.718	.001	9	view →
LIHC	OS	Median	All	0.031	0.775	<.001	6	view →
ESCA	OS	Median	All	0.493	0.705	.031	6	view →
BLCA	DFS	Median	IV	0.090	0.476	.011	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

CYP26B1–UCEC (DFS)

Open the UCEC breakdown →