CYP24A1

Across TCGA patient cohorts, CYP24A1 mutation is significantly associated with the RNA expression of many other genes, with 3,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP24A1-associated genes across cancer lineages are CORT, NFYAP1, and NEURL4. Each is linked with CYP24A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP24A1-to-partner and partner-to-CYP24A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORT grouped by CYP24A1-low versus CYP24A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP24A1→partner) and Y-score (partner→CYP24A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CORT →	+0.446	+3.262	<.001	.008	3	3
LUAD	NFYAP1 →	+0.464	+3.736	<.001	.006	3	3
UCEC	NEURL4 →	+0.403	+2.673	.004	<.001	3	3
UCEC	HAT1 →	+0.518	+2.662	.007	<.001	3	3
UCEC	CHAC2 →	+0.551	+3.343	.006	.005	3	3
UCEC	HSPD1 →	+0.514	+2.700	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,262 associations by consensus.

CORT by CYP24A1 expression — COAD

Explore this box plot interactively →