CYP24A1

Across TCGA patient cohorts, CYP24A1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP24A1-associated genes across cancer lineages are Notch1, PCNA, and Caspase-7-cleavedD198. Each is linked with CYP24A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP24A1-to-partner and partner-to-CYP24A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CYP24A1-low versus CYP24A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP24A1→partner) and Y-score (partner→CYP24A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.129	+2.335	.022	.018	3	2
UCEC	PCNA →	+0.179	+2.584	.039	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+1.079	+3.827	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.627	+1.906	.005	.016	3	2
UCEC	IGFBP2 →	-0.808	-2.321	.001	.033	3	1
UCEC	LKB1 →	-0.086	-1.906	.045	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Notch1 by CYP24A1 expression — UCEC

Explore this box plot interactively →