CYP24A1

Across TCGA cell cohorts, CYP24A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP24A1-associated GO terms across cancer lineages are Vitamin D catabolic process, Cellular response to platelet-derived growth factor stimulus, and Positive regulation of endothelial cell migration. Each is linked with CYP24A1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CYP24A1-to-partner and partner-to-CYP24A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vitamin D catabolic process grouped by CYP24A1-low versus CYP24A1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP24A1→partner) and Y-score (partner→CYP24A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Vitamin D catabolic process →	+1.754	+3.905	<.001	<.001	3	13
OESOPHAGUS	Cellular response to platelet-derived growth factor stimulus →	+0.127	+3.994	.001	<.001	3	7
PANCREAS	Positive regulation of endothelial cell migration →	+0.072	+2.607	.003	<.001	3	6
LARGE_INTESTINE	Establishment of protein localization to membrane →	+0.051	+2.273	<.001	.002	3	6
STOMACH	Lipoprotein biosynthetic process →	+0.091	+1.771	<.001	.009	3	6
STOMACH	mRNA export from nucleus →	+0.103	+2.180	.007	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,100 associations by consensus.

Vitamin D catabolic process by CYP24A1 expression — LIVER

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