CYP24A1

Across TCGA cell cohorts, CYP24A1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP24A1-associated genes across cancer lineages are ETDC, CCDC60, and PRDM7. Each is linked with CYP24A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP24A1-to-partner and partner-to-CYP24A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETDC grouped by CYP24A1-low versus CYP24A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP24A1→partner) and Y-score (partner→CYP24A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ETDC →	+0.483	+5.209	<.001	.005	3	1
SKIN	CCDC60 →	+0.042	+4.347	.004	.001	3	1
LARGE_INTESTINE	PRDM7 →	+0.230	+3.302	<.001	.006	3	1
LARGE_INTESTINE	RBSN →	+0.556	+3.064	.003	.009	3	1
LARGE_INTESTINE	SCN2A →	+0.428	+2.881	<.001	.003	3	1
LARGE_INTESTINE	ASPG →	+0.369	+3.215	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ETDC by CYP24A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →