CYP21A2

Across TCGA patient cohorts, CYP21A2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,648 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CYP21A2-associated proteins across cancer lineages are PRKG1, GTPBP4, and HDGFL3. Each is linked with CYP21A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP21A2-to-partner and partner-to-CYP21A2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP21A2 versus PRKG1 in BRCA, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP21A2→partner) and Y-score (partner→CYP21A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKG1 →	+0.533	+0.887	<.001	<.001	3	4
BRCA	GTPBP4 →	-0.378	-0.992	<.001	<.001	3	4
BRCA	HDGFL3 →	+0.489	+0.593	<.001	.001	3	4
COAD	KANK2 →	+0.429	+0.091	.001	<.001	3	4
HNSC	ANXA6 →	+0.480	+0.167	<.001	.002	3	4
BRCA	LMOD1 →	+0.655	+1.025	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,648 associations by consensus.

CYP21A2 vs PRKG1 — BRCA

Explore this scatter interactively →