CYP21A2

Across TCGA patient cohorts, CYP21A2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP21A2-associated genes across cancer lineages are 4E-BP1, GSK-3a-b_pS21_S9, and Ku80. Each is linked with CYP21A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP21A2-to-partner and partner-to-CYP21A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CYP21A2-low versus CYP21A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP21A2→partner) and Y-score (partner→CYP21A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.332	+2.614	.001	.005	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.381	+1.594	.017	.042	3	1
UCEC	Ku80 →	+0.290	+2.183	.001	.001	3	1
UCEC	MEK1 →	+0.476	+2.321	<.001	.005	3	1
UCEC	Notch1 →	+0.160	+1.765	.002	.014	3	1
UCEC	PCNA →	+0.315	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

4E-BP1 by CYP21A2 expression — UCEC

Explore this box plot interactively →