CYP21A2

Across TCGA cell cohorts, CYP21A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,444 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP21A2-associated GO terms across cancer lineages are Primary alcohol biosynthetic process, Negative regulation of myoblast fusion, and Autophagosome assembly. Each is linked with CYP21A2 in more than 8 cancer types. Because this analysis shows association rather than direction, both CYP21A2-to-partner and partner-to-CYP21A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Primary alcohol biosynthetic process grouped by CYP21A2-low versus CYP21A2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP21A2→partner) and Y-score (partner→CYP21A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Primary alcohol biosynthetic process →	-0.284	-0.247	<.001	.001	3	9
BREAST	Negative regulation of myoblast fusion →	+0.085	+0.261	<.001	.001	2	9
BLOOD_Leukemia	Autophagosome assembly →	+0.031	+0.162	.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.110	+0.233	.001	.002	2	8
BLOOD_Lymphoma	Mineralocorticoid biosynthetic process →	+0.277	+0.455	<.001	.003	3	7
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.088	+0.270	<.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,444 associations by consensus.

Primary alcohol biosynthetic process by CYP21A2 expression — KIDNEY

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