CYP21A2

Across TCGA cell cohorts, CYP21A2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP21A2-associated genes across cancer lineages are OR2D3, ETDC, and MAGEE2. Each is linked with CYP21A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP21A2-to-partner and partner-to-CYP21A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by CYP21A2-low versus CYP21A2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP21A2→partner) and Y-score (partner→CYP21A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2D3 →	+0.027	+4.095	.001	.009	3	1
LARGE_INTESTINE	ETDC →	+0.595	+4.415	<.001	.007	3	1
BLOOD_Leukemia	MAGEE2 →	+0.273	+3.855	<.001	.007	3	1
BLOOD_Leukemia	B3GNT6 →	+0.025	+4.054	.004	.004	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR2D3 by CYP21A2 expression — LARGE_INTESTINE

Explore this box plot interactively →