Across TCGA pan-cancer cohorts, CYP21A1P RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CYP21A1P data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CYP21A1P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP21A1P expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

KIRC, READ, and THCA are the cancer types where CYP21A1P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.535	0.709	<.001	44	view →
READ	DFS	Quartile	All	0.238	0.830	<.001	42	view →
THCA	DFS	Median	II,III,IV	0.602	0.898	<.001	39	view →
ACC	DFS	Tertile	All	0.175	0.702	.004	33	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.389	.010	33	view →
LUAD	DFS	Median	IV	0.240	0.843	.001	31	view →
SKCM	DFS	Tertile	II,III,IV	0.767	0.598	.003	28	view →
LIHC	OS	Tertile	All	0.563	0.755	.002	25	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
BRCA	OS	Tertile	II,III,IV	0.644	0.542	.003	24	view →
MESO	OS	Quartile	III,IV	0.735	0.429	.006	20	view →
LGG	DFS	Tertile	All	0.252	0.555	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: CYP21A1P tumor-vs-normal RNA expression · all CYP21A1P data types