CYP1B1

Across TCGA pan-cancer cohorts, CYP1B1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CYP1B1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CYP1B1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CYP1B1 is over-expressed in tumor.

LSCC, LUAD, and PDAC are the cancer types where CYP1B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP1B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	+0.476	<.001	6	view →
LUAD	All	All	+0.372	<.001	6	view →
PDAC	Female	All	+0.613	.004	4	view →
HNSC	All	IV	+0.362	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CYP1B1–LSCC

Open the LSCC breakdown →