CYP1A2

Across TCGA patient cohorts, CYP1A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,973 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CYP1A2-associated GO terms across cancer lineages are Regulation of mRNA catabolic process, Establishment of RNA localization, and Regulation of nuclear-transcribed mRNA poly(A) tail shortening. Each is linked with CYP1A2 in more than 12 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA catabolic process grouped by CYP1A2-low versus CYP1A2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of mRNA catabolic process →	+0.059	+0.177	<.001	<.001	3	13
STAD	Establishment of RNA localization →	+0.077	+0.169	<.001	<.001	3	11
STAD	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.063	+0.149	<.001	<.001	3	11
STAD	Protein methylation →	+0.059	+0.156	<.001	<.001	3	10
STAD	Lytic vacuole organization →	+0.064	+0.160	<.001	<.001	3	10
STAD	Cellular response to toxic substance →	+0.050	+0.158	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,973 associations by consensus.

Regulation of mRNA catabolic process by CYP1A2 expression — STAD

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