CYP1A2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYP1A2 protein abundance is significantly associated with the RNA expression of many other genes, with 845 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CYP1A2-associated genes across cancer lineages are BCL11A, AIG1, and KLK6. Each is linked with CYP1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP1A2 versus BCL11A in HNSC, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCBCL11A →+1.301+1.066<.001<.00132
BRCAAIG1 →+1.045+2.380.001.00132
HNSCKLK6 →-3.621-1.066<.001<.00132
HNSCZBTB18 →+1.264+1.277.005.00632
HNSCTRAPPC12-AS1 →+0.938+1.066<.001<.00132
HNSCIFT80 →+0.872+1.379.002.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

CYP1A2 vs BCL11A — HNSC

Per-sample scatter of CYP1A2 vs BCL11A in HNSC (Pearson r = 0.83).

Explore this scatter interactively →

Exploration