CYP1A2

Across TCGA patient cohorts, CYP1A2 mutation is significantly associated with the RNA expression of many other genes, with 1,013 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1A2-associated genes across cancer lineages are SIGLEC17P, PPP2R2D, and LINC01139. Each is linked with CYP1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC17P grouped by CYP1A2-low versus CYP1A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SIGLEC17P →	-0.301	-3.695	.009	<.001	3	2
SKCM	PPP2R2D →	+0.257	+2.932	.007	<.001	3	2
UCEC	LINC01139 →	-0.997	-2.676	.001	.006	3	2
UCEC	SUSD2 →	-0.925	-2.796	.003	.003	3	2
UCEC	DOC2B →	-0.813	-2.000	.004	.009	3	2
HNSC	PRORY →	+1.135	+4.624	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,013 associations by consensus.

SIGLEC17P by CYP1A2 expression — SKCM

Explore this box plot interactively →