CYP1A2

Across TCGA patient cohorts, CYP1A2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1A2-associated genes across cancer lineages are mTOR_pS2448, VHL, and Cyclin-B1. Each is linked with CYP1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CYP1A2-low versus CYP1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.140	-3.446	.010	.005	3	2
UCEC	VHL →	-0.984	-2.906	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.744	+2.736	<.001	<.001	3	2
SKCM	ACC1 →	+0.292	+2.182	.025	.033	3	1
SKCM	Paxillin →	-0.346	-1.700	.045	.043	3	1
SKCM	PKC-b-II_pS660 →	-0.256	-1.700	.038	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

mTOR_pS2448 by CYP1A2 expression — UCEC

Explore this box plot interactively →