CYP1A2

Across TCGA cell cohorts, CYP1A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 359 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible CYP1A2-associated GO terms across cancer lineages are Isopentenyl diphosphate biosynthetic process, mevalonate pathway, U2-type prespliceosome assembly, and Viral life cycle. Each is linked with CYP1A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Isopentenyl diphosphate biosynthetic process, mevalonate pathway grouped by CYP1A2-low versus CYP1A2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Isopentenyl diphosphate biosynthetic process, mevalonate pathway →	+0.120	+0.114	<.001	.005	3	4
CNS	U2-type prespliceosome assembly →	+0.052	+0.006	.004	.006	3	4
BLOOD_Lymphoma	Viral life cycle →	+0.040	+0.088	<.001	.004	2	4
BLOOD_Lymphoma	Primary alcohol metabolic process →	-0.033	-0.071	.001	.006	2	4
CNS	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.029	-0.006	.004	.003	2	4
OVARY	Regulation of activated T cell proliferation →	+0.145	+0.374	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

Isopentenyl diphosphate biosynthetic process, mevalonate pathway by CYP1A2 expression — BLOOD_Lymphoma

Explore this box plot interactively →