CYP1A2

Across TCGA cell cohorts, CYP1A2 mutation is significantly associated with the mutation status of many other genes, with 2,895 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP1A2-associated genes across cancer lineages are NME8, PARP4, and SLC7A3. Each is linked with CYP1A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP1A2-to-partner and partner-to-CYP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NME8 grouped by CYP1A2-low versus CYP1A2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A2→partner) and Y-score (partner→CYP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NME8 →	+2.473	+3.139	.002	.002	1	3
LARGE_INTESTINE	PARP4 →	+2.407	+2.886	.008	.008	1	3
LUNG_SCLC	SLC7A3 →	+5.502	+5.502	.003	.003	1	3
SKIN	DYNC1H1 →	+2.058	+2.799	.006	.006	1	3
BLOOD_Lymphoma	EPB42 →	+4.169	+5.316	<.001	<.001	1	3
BLOOD_Lymphoma	HCFC1 →	+3.362	+4.754	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,895 associations by consensus.

NME8 by CYP1A2 expression — SKIN

Explore this box plot interactively →