CYP1A1

Across TCGA pan-cancer cohorts, CYP1A1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CYP1A1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYP1A1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP1A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, UCEC, and SCLC are the cancer types where CYP1A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.124	0.697	<.001	51	view →
UCEC	DFS	Median	All	0.961	0.601	.008	26	view →
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	24	view →
OV	DFS	Median	All	0.265	0.541	.032	18	view →
PAAD	DFS	Median	All	0.100	0.484	.003	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
COAD	DFS	Median	All	0.170	0.790	.002	12	view →
ESCA	DFS	Median	III,IV	0.080	0.442	<.001	6	view →
STAD	OS	Median	III,IV	1.000	0.367	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CYP1A1–HNSC (DFS)

Open the HNSC breakdown →