CYP1A1

Across TCGA patient cohorts, CYP1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,785 significant associations in total. LGG shows the largest number of these associations.

The most reproducible CYP1A1-associated GO terms across cancer lineages are ER overload response, Dendritic spine development, and Endosomal lumen acidification. Each is linked with CYP1A1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER overload response grouped by CYP1A1-low versus CYP1A1-high in BLCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ER overload response →	+0.041	+1.583	<.001	<.001	3	9
GBM	Dendritic spine development →	+0.033	+0.170	<.001	<.001	3	9
LGG	Endosomal lumen acidification →	+0.037	+0.253	<.001	<.001	3	9
UVM	Protein hydroxylation →	+0.034	+0.161	<.001	.004	3	9
UCEC	Negative regulation of TORC1 signaling →	+0.026	+0.143	<.001	<.001	2	10
GBM	Glucan biosynthetic process →	+0.034	+0.126	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,785 associations by consensus.

ER overload response by CYP1A1 expression — BLCA

Explore this box plot interactively →