CYP1A1

Across TCGA patient cohorts, CYP1A1 protein abundance is significantly associated with the RNA expression of many other genes, with 742 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CYP1A1-associated genes across cancer lineages are NOD2, RNU6-34P, and RNU6-650P. Each is linked with CYP1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP1A1 versus NOD2 in LSCC, with a Pearson correlation of -0.18.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NOD2 →	-0.709	-0.285	.008	.009	3	1
LSCC	RNU6-34P →	+0.363	+0.855	.003	<.001	3	1
LSCC	RNU6-650P →	+0.353	+0.578	.009	.007	3	1
LSCC	BTBD7P1 →	+0.774	+0.323	.002	.005	3	1
LSCC	RNU6-15P →	+0.621	+0.470	<.001	.008	3	1
LSCC	PGK1P2 →	+0.292	+0.331	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 742 associations by consensus.

CYP1A1 vs NOD2 — LSCC

Explore this scatter interactively →