CYP1A1

Across TCGA patient cohorts, CYP1A1 mutation is significantly associated with the RNA expression of many other genes, with 1,266 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1A1-associated genes across cancer lineages are RNU6-362P, RNA5SP416, and RNU6-285P. Each is linked with CYP1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-362P grouped by CYP1A1-low versus CYP1A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-362P →	+0.363	+7.954	<.001	.008	3	3
LUSC	RNA5SP416 →	+0.547	+4.733	<.001	<.001	3	3
BLCA	RNU6-285P →	+0.298	+4.685	<.001	.007	3	3
READ	MTATP6P20 →	+0.255	+6.681	<.001	<.001	3	2
READ	RPL9P15 →	+0.164	+5.925	<.001	.002	3	2
READ	RPL12P5 →	+0.216	+5.219	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,266 associations by consensus.

RNU6-362P by CYP1A1 expression — HNSC

Explore this box plot interactively →