CYP1A1

Across TCGA cell cohorts, CYP1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,302 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CYP1A1-associated GO terms across cancer lineages are Phenylpropanoid metabolic process, Coumarin metabolic process, and Hydrocarbon metabolic process. Each is linked with CYP1A1 in more than 15 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phenylpropanoid metabolic process grouped by CYP1A1-low versus CYP1A1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Phenylpropanoid metabolic process →	+1.510	+3.087	<.001	<.001	3	16
LIVER	Coumarin metabolic process →	+1.510	+3.087	<.001	<.001	3	16
URINARY_TRACT	Hydrocarbon metabolic process →	+2.189	+4.147	<.001	<.001	3	12
PANCREAS	Response to iron(III) ion →	-0.168	-0.898	<.001	<.001	3	12
URINARY_TRACT	Lipid hydroxylation →	+1.243	+2.611	<.001	<.001	3	11
STOMACH	Maternal process involved in parturition →	+1.463	+3.816	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,302 associations by consensus.

Phenylpropanoid metabolic process by CYP1A1 expression — LIVER

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