CYP1A1

Across TCGA cell cohorts, CYP1A1 mutation is significantly associated with the mutation status of many other genes, with 2,201 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP1A1-associated genes across cancer lineages are DCLK2, TNKS1BP1, and LRRC43. Each is linked with CYP1A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLK2 grouped by CYP1A1-low versus CYP1A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCLK2 →	+3.313	+3.430	.005	.005	1	4
SKIN	TNKS1BP1 →	+4.392	+4.392	.009	.009	1	4
SKIN	LRRC43 →	+3.655	+4.906	.001	.001	1	4
LUNG_NSCLC_LUAD	ABL1 →	+5.000	+4.187	.008	.008	1	4
LARGE_INTESTINE	OTOA →	+2.893	+3.222	.003	.003	1	4
LARGE_INTESTINE	XDH →	+2.099	+4.064	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,201 associations by consensus.

DCLK2 by CYP1A1 expression — BLOOD_Leukemia

Explore this box plot interactively →