CYP1A1

Across TCGA cell cohorts, CYP1A1 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP1A1-associated genes across cancer lineages are GSK2801, IC-87114, and PF-00299804. Each is linked with CYP1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1A1-to-partner and partner-to-CYP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2801 grouped by CYP1A1-low versus CYP1A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1A1→partner) and Y-score (partner→CYP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2801 →	+0.316	+2.649	.047	.046	3	1
LARGE_INTESTINE	IC-87114 →	+0.206	+2.652	.046	.045	3	1
LARGE_INTESTINE	PF-00299804 →	+0.573	+2.652	.014	.045	3	1
LARGE_INTESTINE	Voxtalisib →	+0.359	+2.652	.009	.045	3	1
LARGE_INTESTINE	AST-1306 →	+0.600	+2.684	.006	.035	3	1
LARGE_INTESTINE	AZD5438 →	+0.490	+2.777	.047	.038	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GSK2801 by CYP1A1 expression — LARGE_INTESTINE

Explore this box plot interactively →