CYP19A1

Across TCGA cell cohorts, CYP19A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,269 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYP19A1-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with CYP19A1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP19A1-to-partner and partner-to-CYP19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by CYP19A1-low versus CYP19A1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP19A1→partner) and Y-score (partner→CYP19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.095	+0.243	.002	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.089	+0.243	.004	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.086	+0.227	.001	.009	3	8
PANCREAS	Regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.298	<.001	.009	3	8
BLOOD_Lymphoma	Isoprenoid catabolic process →	+0.910	+1.910	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.050	+0.262	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,269 associations by consensus.

Negative regulation of myoblast fusion by CYP19A1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →