CYP19A1

Across TCGA cell cohorts, CYP19A1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYP19A1-associated genes across cancer lineages are SEPTIN14 and P2RY13. Each is linked with CYP19A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP19A1-to-partner and partner-to-CYP19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14 grouped by CYP19A1-low versus CYP19A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP19A1→partner) and Y-score (partner→CYP19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LUNG_NSCLC_LUAD	P2RY13 →	+0.020	+4.312	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SEPTIN14 by CYP19A1 expression — LARGE_INTESTINE

Explore this box plot interactively →