CYP17A1

Across TCGA patient cohorts, CYP17A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,151 significant associations in total. THYM shows the largest number of these associations.

The most reproducible CYP17A1-associated GO terms across cancer lineages are Nucleoside bisphosphate metabolic process, Branched-chain amino acid catabolic process, and Methylglyoxal metabolic process. Each is linked with CYP17A1 in more than 16 cancer types. Because this analysis shows association rather than direction, both CYP17A1-to-partner and partner-to-CYP17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside bisphosphate metabolic process grouped by CYP17A1-low versus CYP17A1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP17A1→partner) and Y-score (partner→CYP17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Nucleoside bisphosphate metabolic process →	+0.066	+0.627	<.001	<.001	3	17
UVM	Branched-chain amino acid catabolic process →	+0.053	+0.530	<.001	<.001	3	16
LUAD	Methylglyoxal metabolic process →	+0.042	+0.273	<.001	<.001	3	16
UCS	ATP biosynthetic process →	+0.041	+0.956	<.001	.004	2	16
UVM	Proton motive force-driven ATP synthesis →	+0.038	+0.342	<.001	<.001	3	15
ESCA	Carbohydrate catabolic process →	+0.049	+0.552	.004	.004	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,151 associations by consensus.

Nucleoside bisphosphate metabolic process by CYP17A1 expression — STAD

Explore this box plot interactively →