CYP17A1

Across TCGA patient cohorts, CYP17A1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP17A1-associated genes across cancer lineages are eEF2, INPP4B, and MEK1. Each is linked with CYP17A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP17A1-to-partner and partner-to-CYP17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CYP17A1-low versus CYP17A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP17A1→partner) and Y-score (partner→CYP17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.302	+2.178	.030	.035	3	2
COAD	INPP4B →	-0.376	-3.000	.032	.035	3	2
UCEC	MEK1 →	+0.476	+3.807	.001	<.001	3	2
UCEC	4E-BP1 →	+0.289	+3.199	.009	.009	3	2
COAD	Cyclin-B1 →	+0.678	+3.330	.008	.005	3	2
COAD	Di-Ras3 →	-0.189	-3.169	.039	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eEF2 by CYP17A1 expression — COAD

Explore this box plot interactively →