CYP17A1

Across TCGA cell cohorts, CYP17A1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP17A1-associated genes across cancer lineages are ECE2, UBE2QL1, and NPAP1. Each is linked with CYP17A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP17A1-to-partner and partner-to-CYP17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by CYP17A1-low versus CYP17A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP17A1→partner) and Y-score (partner→CYP17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.360	+4.054	<.001	.004	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.312	+3.722	<.001	.007	3	1
BREAST	NPAP1 →	+0.013	+5.169	<.001	.005	3	1
BREAST	OR2G6 →	+0.012	+5.169	<.001	.005	3	1
LARGE_INTESTINE	SCN11A →	+0.160	+3.772	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ECE2 by CYP17A1 expression — LARGE_INTESTINE

Explore this box plot interactively →